2019 January 1
Harshana Lakmal and Dhanushan Wijayaratna joined the group. Welcome Harshana and Dhanushan !
CLARIFICATION: OUR FINDINGS DO NOT SHOW THAT LIGHT FROM DIGITAL DEVISES CAUSES BLINDNESS!
To the public: Our Scientific Reports article recently captured media attention https://www.nature.com/articles/s41598-018-28254-8. We caution the public that our study does not show that light from mobile devises or other digital screens causes blindness. What we demonstrate is that, in the presence of the photoreceptor chromophore “retinal”, the molecules that photoreceptor cells in the eye utilize to sense light, blue light perturbs cell signaling and induces cells death. Whether blue light from mobile devises and digital screens induces similar toxicity levels is an unanswered question and is currently under investigation. Even if such a scenario is found, since the studies are done in cultured cells, that would not indicate that these devises can cause similar damages to the vision. Nevertheless, some literature reports suggest that removal of blue component from intense light can reduce vision damages ( http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194218 ).
2018 August 8
Highlights of recent research on blue light excited retinal induced cellular signaling perturbation is aired on 13ABC.
Highlights of recent research on blue light excited retinal induced cellular signaling perturbation is published on UT news.
UT CHEMISTS DISCOVER HOW BLUE LIGHT SPEEDS BLINDNESS
2018 July 5
THE LATEST RESEARCH ARTICLE ON MECHANISMS OF LIGHT AND AGE-RELATED BLINDNESS FROM MY RESEARCH GROUP AT @CHEMISTRYTOLEDO IN @UTOLEDO. CONGRATULATIONS TO AUTHORS!
Ratnayake, K., Payton, J. L., Lakmal, O. H., and Karunarathne, A. (2018) Blue light excited retinal intercepts cellular signaling. Scientific Reports 8, 10207 https://www.nature.com/articles/s41598-018-28254-8
2018 June 11
OUR RESEARCH SHEDS A NEW LIGHT ON GPCR REGULATION BY G PROTEINS. CONGRATULATIONS TO AUTHORS!
Samaradivakara, S., Kankanamge, D., Senarath, K., Ratnayake, K., and Karunarathne, A. (2018) G protein gamma (Ggamma ) subtype dependent targeting of GRK2 to M3 receptor by Gbetagamma. Biochemical Biophysical Research Communications, 2018 Jun 11. pii: S0006-291X(18)31295-6.
2018 April 29:
Paper titled “Melanopsin (Opn4) employs Gαi and Gβγ as major signal transducers” is published in Journal of Cell Science. Congratulations the authors : Dinesh Kankanamge, Kasun Ratnayake, Saroopa Samaradivakara, Ajith Karunarathne
2018 March 28:
Book Chapter titled “Regulation of G Protein βγ Signaling”” is published in the latest edition of International Review of Cell and Molecular Biology. Congratulations authors : Kanishka Senarath, Dinesh Kankanamge, Saroopa Samaradivakara, Kasun Ratnayake, Mithila Tennakoon, Ajith Karunarathne
2017-2018 research highlights were published in UT news.
2018 January 5:
Paper titled “Gγ identity dictates efficacy of Gβγ signaling and macrophage migration ” is published in Journal of Biological chemistry. Congratulations the authors : Kanishka Senarath, John L.Payton, Dinesh Kankanamge, Praneeth Siripurapu, Mithila Tennakoon, AjithKarunarathne
2017 September 19:
Book Chapter titled “Measurement of GPCR-G protein activity in living cells” is published in the latest edition of Methods in Cell Biology, Volume 142, 2017, Pages 1-25. Congratulations authors : Kasun Ratnayake, Dinesh Kankanamge, Kanishka Senarath, Praneeth Siripurapu, Nicole Weis, Mithila Tennakoon, John L.Payton, Ajith Karunarathne
2017 September 1:
Our paper titled ” Two independent but synchronized Gβγ subunit−controlled pathways are essential for trailing-edge retraction during macrophage migration ” is published in Journal of Biological chemistry. Congratulations the authors : Praneeth Siripurapu, Dinesh Kankanamge, Kasun Ratnayake, Kanishka Senarath, AjithKarunarathne
Praneeth successfully defended his Masters’ Thesis. Congratulations!
Mithila Tennakoon and Saroopa Samaradiwakara joined the group. Welcome Mithila and Saroopa !
Kaushy Gera, Kayla Kucway and Scott Ross , three high school students from Northview Highschool, Sylvania have joined the lab to work on a summer research project starting from June, 2017. Welcome Kaushy, Kayla and Scott and goodluck with the research project..!!!
Dinesh attended and succesfully completed a workshop organized by Transgenic Animal Model Core and Biomedical Research Core Facilities at University of Michigan on CRISPR/Cas9 training for genome engineering design.
Our Collaborative work with Dr. Lopa Giri Mudra from IIT, Hyderabad, India was published in SLAS discovery titled “COMPARISON OF CALCIUM DYNAMICS AND SPECIFIC FEATURES FOR G PROTEIN-COUPLED RECEPTOR-TARGETING DRUGS USING LIVE CELL IMAGING AND AUTOMATED ANALYSIS”. Congratulations authors!
Gupta, R. K., Swain, S., Kankanamge, D., Priyanka, P. D., Singh, R., Mitra, K., Karunarathne, A., and Giri, L. (2017) . SLAS discovery, 2472555217693378
Our recent work titled “Reversible G protein βγ9 distribution based assay reveals molecular underpinnings in sub cellular, single & multicellular GPCR and G protein activity” is published in Analytical Chemistry. Congratulations to the authors; Kanishka, Kasun, John and Praneeth.
Senarath K, Ratnayake K, Siripurapu P, Payton JL, Karunarathne A. Reversible G Protein βγ9 Distribution-Based Assay Reveals Molecular Underpinnings in Subcellular, Single-Cell, and Multicellular GPCR and G Protein Activity.Anal Chem. 2016 Dec 6;88(23):11450-11459. PubMed PMID: 27778511.
Our findings on itch sensation is now published in the journal SCIENCE SIGNALING. Click here to read it.
Our review article Titled ” Subcellular optogenetics: controlling signaling and single cell behavior” is published in JOURNAL OF CELL SCIENCES.
Our findings are published in the journal NEURON on cross talks between Serotonin (5HT)- gastrin releasing peptide (GRP) receptors and subsequent effects on itch sensation. This new is on NBC news national coverage.
We offer a science outreach program for high school students to conduct research in life sciences!